help  | about  | cite  | software

Gene : CARD8 Homo sapiens

Name  ? caspase recruitment domain family member 8 Cytological Location  19q13.33
Brief Description  caspase recruitment domain family member 8
Description  The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
  • synonyms:
  • AB023172,
  • DAKAR,
  • Dakar,
  • CARD8,
  • HGNC:17057,
  • uc061ark.1,
  • DACAR,
  • NDPP,
  • caspase recruitment domain family, member 8,
  • TUCAN,
  • NM_014959,
  • NDPP1,
  • KIAA0955,
  • TUCAN,
  • NDPP,
  • OTTHUMG00000165047
  • identifiers:
  • 22900,
  • ENSG00000105483,
  • CARD8

Genome feature

Region: gene ? Length: 53117  
Location: 19:48203148-48256264 reverse strand Cyto location: 19q13.33

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3740 SN Ps

5 Cross References

17 Data Sets

0 Homologues

0 Located Features

97 Rna Seq Results