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Gene : CARD8 Homo sapiens

Name  ? caspase recruitment domain family member 8 Cytological Location  19q13.33
Brief Description  caspase recruitment domain family member 8
Description  The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
  • synonyms:
  • DAKAR,
  • TUCAN,
  • CARDINAL,
  • AB023172,
  • NDPP,
  • Dakar,
  • uc061ark.1,
  • NDPP1,
  • CARDINAL,
  • CARD8,
  • HGNC:17057,
  • KIAA0955,
  • OTTHUMG00000165047,
  • TUCAN,
  • DACAR,
  • NM_014959,
  • NDPP,
  • caspase recruitment domain family, member 8
  • identifiers:
  • 22900,
  • ENSG00000105483,
  • CARD8

Genome feature

Region: gene ? Length: 53117  
Location: 19:48203148-48256264 reverse strand Cyto location: 19q13.33


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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

3756 SN Ps

5 Cross References

17 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results