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Gene : DAAM1 Homo sapiens

Name  ? dishevelled associated activator of morphogenesis 1 Cytological Location  14q23.1
Brief Description  dishevelled associated activator of morphogenesis 1
Description  Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
  • synonyms:
  • AB014566,
  • uc001xea.3,
  • NM_014992,
  • OTTHUMG00000140326,
  • HGNC:18142,
  • KIAA0666,
  • DAAM1
  • identifiers:
  • 23002,
  • ENSG00000100592,
  • DAAM1

Genome feature

Region: gene ? Length: 182749  
Location: 14:59188657-59371405 Cyto location: 14q23.1


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3753 SN Ps

5 Cross References

18 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results