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Gene : ATG4B Homo sapiens

Name  ? autophagy related 4B cysteine peptidase Cytological Location  2q37.3
Brief Description  autophagy related 4B cysteine peptidase
Description  Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • synonyms:
  • APG4B,
  • autophagy related 4B, cysteine peptidase,
  • uc002wbv.4,
  • KIAA0943,
  • HGNC:20790,
  • APG4 autophagy 4 homolog B (S. cerevisiae),
  • APG4B,
  • ATG4 autophagy related 4 homolog B (S. cerevisiae),
  • DKFZp586D1822,
  • NM_013325,
  • Apg4B,
  • ATG4B,
  • AUTL1,
  • AUTL1,
  • OTTHUMG00000151514,
  • AB023160
  • identifiers:
  • 23192,
  • ENSG00000168397,
  • ATG4B

Genome feature

Region: gene ? Length: 36199  
Location: 2:241637659-241673857 Cyto location: 2q37.3

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2 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



2 Pathways

3740 SN Ps

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results