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Gene : FLT1 Homo sapiens

Name  ? fms related receptor tyrosine kinase 1 Cytological Location  13q12.3
Brief Description  fms related receptor tyrosine kinase 1
Description  This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
  • synonyms:
  • VEGFR1,
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor),
  • FLT-1,
  • NM_002019,
  • VEGFR1,
  • AF063657,
  • uc001usb.4,
  • fms-related tyrosine kinase 1,
  • FLT,
  • vascular permeability factor receptor,
  • fms related tyrosine kinase 1,
  • FLT,
  • FLT1,
  • OTTHUMG00000016648,
  • vascular endothelial growth factor receptor 1,
  • HGNC:3763,
  • VEGFR-1
  • identifiers:
  • 2321,
  • ENSG00000102755,
  • FLT1

Genome feature

Region: gene ? Length: 194783  
Location: 13:28300346-28495128 reverse strand Cyto location: 13q12.3

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0 Diseases

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130 SN Ps

5 Cross References

18 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results