help  | about  | cite  | software

Gene : FLT1 Homo sapiens

Name  ? fms related receptor tyrosine kinase 1 Cytological Location  13q12.3
Brief Description  fms related receptor tyrosine kinase 1
Description  This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
  • synonyms:
  • VEGFR1,
  • fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor),
  • FLT-1,
  • NM_002019,
  • VEGFR1,
  • AF063657,
  • uc001usb.4,
  • fms-related tyrosine kinase 1,
  • FLT,
  • vascular permeability factor receptor,
  • fms related tyrosine kinase 1,
  • FLT,
  • FLT1,
  • OTTHUMG00000016648,
  • vascular endothelial growth factor receptor 1,
  • HGNC:3763,
  • VEGFR-1
  • identifiers:
  • 2321,
  • ENSG00000102755,
  • FLT1

Genome feature

Region: gene ? Length: 194783  
Location: 13:28300346-28495128 reverse strand Cyto location: 13q12.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

130 SN Ps

5 Cross References

18 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results