help  | about  | cite  | software

Gene : FLT3 Homo sapiens

Name  ? fms related receptor tyrosine kinase 3 Cytological Location  13q12.2
Brief Description  fms related receptor tyrosine kinase 3
Description  This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
  • synonyms:
  • fms-related tyrosine kinase 3,
  • fms related tyrosine kinase 3,
  • FLK2,
  • NM_004119,
  • FLK-2,
  • STK1,
  • FLT3,
  • uc001urw.3,
  • CD135,
  • OTTHUMG00000016646,
  • CD135,
  • FLK2,
  • U02687,
  • HGNC:3765,
  • STK1
  • identifiers:
  • 2322,
  • ENSG00000122025,
  • FLT3

Genome feature

Region: gene ? Length: 97314  
Location: 13:28003274-28100587 reverse strand Cyto location: 13q12.2

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

19 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results