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Gene : FBXW11 Homo sapiens

Name  ? F-box and WD repeat domain containing 11 Cytological Location  5q35.1
Brief Description  F-box and WD repeat domain containing 11
Description  This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]
  • synonyms:
  • Fbw11,
  • Hos,
  • FBXW1B,
  • FBXW11,
  • AB014596,
  • Fbw1b,
  • FBXW1B,
  • BTRC2,
  • HGNC:13607,
  • FBW1B,
  • BTRC2,
  • Hos,
  • KIAA0696,
  • F-box and WD-40 domain protein 11,
  • uc003mbl.2,
  • Fbw11,
  • BTRCP2,
  • F-box and WD-40 domain protein 1B,
  • NM_012300,
  • OTTHUMG00000163267,
  • BTRCP2
  • identifiers:
  • 23291,
  • ENSG00000072803,
  • FBXW11

Genome feature

Region: gene ? Length: 148056  
Location: 5:171861549-172009604 reverse strand Cyto location: 5q35.1

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54 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

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Gene --> Proteins.


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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



54 Pathways

31 SN Ps

5 Cross References

18 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results