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Gene : FMOD Homo sapiens

Name  ? fibromodulin Cytological Location  1q32.1
Brief Description  fibromodulin
Description  Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
  • synonyms:
  • U05291,
  • fibromodulin proteoglycan,
  • SLRR2E,
  • FMOD,
  • uc001gzr.5,
  • SLRR2E,
  • FM,
  • OTTHUMG00000035910,
  • NM_002023,
  • HGNC:3774
  • identifiers:
  • 2331,
  • ENSG00000122176,
  • FMOD

Genome feature

Region: gene ? Length: 10495  
Location: 1:203340628-203351122 reverse strand Cyto location: 1q32.1


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

Gene --> Proteins.

SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

3753 SN Ps

5 Cross References

15 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results