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Gene : CELA3B Homo sapiens

Name  ? chymotrypsin like elastase 3B Cytological Location  1p36.12
Brief Description  chymotrypsin like elastase 3B
Description  Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]
  • synonyms:
  • NM_007352,
  • uc001bfk.4,
  • ELA3B,
  • CBPP,
  • pancreatic endopeptidase E,
  • CBPP,
  • chymotrypsin-like elastase family, member 3B,
  • CELA3B,
  • ELA3B,
  • proteinase E,
  • HGNC:15945,
  • cholesterol-binding pancreatic protease,
  • elastase 1,
  • OTTHUMG00000002758,
  • M18692,
  • elastase 3B, pancreatic
  • identifiers:
  • 23436,
  • ENSG00000219073,
  • CELA3B

Genome feature

Region: gene ? Length: 12333  
Location: 1:21977022-21989354 Cyto location: 1p36.12


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Disease

0 Diseases

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Other

348 SN Ps

5 Cross References

16 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results