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Gene : CLCF1 Homo sapiens

Name  ? cardiotrophin like cytokine factor 1 Cytological Location  11q13.2
Brief Description  cardiotrophin like cytokine factor 1
Description  This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
  • synonyms:
  • CISS2,
  • NNT-1,
  • cold-induced sweating syndrome 2,
  • OTTHUMG00000167669,
  • NNT1,
  • uc001okq.4,
  • BSF-3,
  • NM_013246,
  • CLC,
  • NNT1,
  • CISS2,
  • BSF3,
  • NR6,
  • novel neurotrophin-1,
  • NNT-1,
  • CLC,
  • BSF-3,
  • HGNC:17412,
  • CLCF1,
  • CRLF1 associated cytokine-like factor 1,
  • BC012939,
  • BSF3,
  • B-cell stimulating factor 3,
  • NR6
  • identifiers:
  • 23529,
  • ENSG00000175505,
  • CLCF1

Genome feature

Region: gene ? Length: 10010  
Location: 11:67364168-67374177 reverse strand Cyto location: 11q13.2

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1 Diseases

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99 SN Ps

5 Cross References

18 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results