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Gene : CASP14 Homo sapiens

Name  ? caspase 14 Cytological Location  19p13.12
Brief Description  caspase 14
Description  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]
  • synonyms:
  • MGC119079,
  • HGNC:1502,
  • uc010dzv.3,
  • CASP14,
  • OTTHUMG00000183205,
  • caspase 14, apoptosis-related cysteine protease,
  • caspase 14, apoptosis-related cysteine peptidase,
  • NM_012114,
  • MGC119078,
  • MICE,
  • ARCI12,
  • apoptosis-related cysteine protease
  • identifiers:
  • 23581,
  • ENSG00000105141,
  • CASP14

Genome feature

Region: gene ? Length: 8814  
Location: 19:15049480-15058293 Cyto location: 19p13.12

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Gene -> HPO annotation (Human Phenotype Ontology)

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1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



142 SN Ps

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results