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Gene : ALOX5AP Homo sapiens

Name  ? arachidonate 5-lipoxygenase activating protein Cytological Location  13q12.3
Brief Description  arachidonate 5-lipoxygenase activating protein
Description  This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
  • synonyms:
  • MK-886-binding protein,
  • uc001utf.3,
  • ALOX5AP,
  • arachidonate 5-lipoxygenase-activating protein,
  • NM_001629,
  • HGNC:436,
  • OTTHUMG00000016677,
  • AH001462,
  • five-lipoxygenase activating protein,
  • FLAP,
  • FLAP
  • identifiers:
  • 241,
  • ENSG00000132965,

Genome feature

Region: gene ? Length: 50951  
Location: 13:30713478-30764428 Cyto location: 13q12.3

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Gene -> HPO annotation (Human Phenotype Ontology)

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1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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281 SN Ps

5 Cross References

19 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results