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Gene : BACE2 Homo sapiens

Name  ? beta-secretase 2 Cytological Location  21q22.2-q22.3
Brief Description  beta-secretase 2
Description  This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  • synonyms:
  • ALP56,
  • uc002yyw.5,
  • DRAP,
  • HGNC:934,
  • ALP56,
  • NM_012105,
  • memapsin 1,
  • AF117892,
  • CEAP1,
  • ASP21,
  • beta-site APP-cleaving enzyme 2,
  • BACE2,
  • DRAP,
  • AEPLC,
  • CEAP1,
  • BAE2,
  • OTTHUMG00000086742,
  • ASP1,
  • CDA13,
  • AEPLC
  • identifiers:
  • 25825,
  • ENSG00000182240,
  • BACE2

Genome feature

Region: gene ? Length: 114371  
Location: 21:41168160-41282530 Cyto location: 21q22.2-q22.3


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Function

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1 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

1 Pathways

3753 SN Ps

5 Cross References

18 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results