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Gene : GCK Homo sapiens

Name  ? glucokinase Cytological Location  7p13
Brief Description  glucokinase
Description  This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]
  • synonyms:
  • LGLK,
  • MODY2,
  • HK4,
  • FGQTL3,
  • NM_000162,
  • HK4,
  • uc003tkl.3,
  • HGNC:4195,
  • AF041014,
  • GCK,
  • HKIV,
  • HXKP,
  • OTTHUMG00000022903,
  • glucokinase (hexokinase 4),
  • GLK,
  • hexokinase 4,
  • HHF3,
  • maturity onset diabetes of the young 2,
  • MODY2,
  • GK
  • identifiers:
  • 2645,
  • ENSG00000106633,
  • GCK

Genome feature

Region: gene ? Length: 46227  
Location: 7:44143213-44189439 reverse strand Cyto location: 7p13

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4 Diseases

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3753 SN Ps

5 Cross References

20 Data Sets

15 Homologues

0 Located Features

97 Rna Seq Results