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Gene : AGO1 Homo sapiens

Name  ? argonaute RISC component 1 Cytological Location  1p34.3
Brief Description  argonaute RISC component 1
Description  This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]
  • synonyms:
  • EIF2C,
  • EIF2C1,
  • argonaute RISC catalytic component 1,
  • argonaute 1,
  • AGO1,
  • eukaryotic translation initiation factor 2C, 1,
  • NM_001317122,
  • uc001bzl.5,
  • GERP95,
  • Q99,
  • hAgo1,
  • OTTHUMG00000007381,
  • hAGO1,
  • EIF2C1,
  • AF093097,
  • HGNC:3262
  • identifiers:
  • 26523,
  • ENSG00000092847,
  • AGO1

Genome feature

Region: gene ? Length: 60772  
Location: 1:35869761-35930532 Cyto location: 1p34.3

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



219 SN Ps

5 Cross References

15 Data Sets

24 Homologues

0 Located Features

97 Rna Seq Results