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Gene : GREM1 Homo sapiens

Name  ? gremlin 1, DAN family BMP antagonist Cytological Location  15q13.3
Brief Description  gremlin 1, DAN family BMP antagonist
Description  This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • synonyms:
  • PIG2,
  • IHG-2,
  • MPSH,
  • DAND2,
  • gremlin 1,
  • C15DUPq,
  • GREM1,
  • colorectal adenoma and carcinoma 1,
  • HMPS,
  • cysteine knot superfamily 1, BMP antagonist 1,
  • DRM,
  • HGNC:2001,
  • DUP15q,
  • hereditary mixed polyposis syndrome,
  • CRAC1,
  • CRCS4,
  • NM_013372,
  • gremlin,
  • DAND2,
  • OTTHUMG00000129319,
  • CKTSF1B1,
  • HMPS1,
  • HMPS,
  • down-regulated in mos-transformed cells,
  • CRAC1,
  • gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis),
  • DRM,
  • uc001zhe.3,
  • CKTSF1B1
  • identifiers:
  • 26585,
  • ENSG00000166923,
  • GREM1

Genome feature

Region: gene ? Length: 27103  
Location: 15:32718004-32745106 Cyto location: 15q13.3

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

290 SN Ps

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results