help  | about  | cite  | software

Gene : GFRA1 Homo sapiens

Name  ? GDNF family receptor alpha 1 Cytological Location  10q25.3
Brief Description  GDNF family receptor alpha 1
Description  This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
  • synonyms:
  • GDNFR,
  • GDNFRA,
  • HGNC:4243,
  • RETL1,
  • RET1L,
  • GFR-ALPHA-1,
  • GDNFR,
  • GFRA1,
  • TRNR1,
  • TRNR1,
  • RET1L,
  • AF038421,
  • OTTHUMG00000019097,
  • RETL1,
  • GFR-ALPHA-1,
  • NM_145793,
  • GDNFRA,
  • uc009xyr.4
  • identifiers:
  • 2674,
  • ENSG00000151892,
  • GFRA1

Genome feature

Region: gene ? Length: 216721  
Location: 10:116056925-116273645 reverse strand Cyto location: 10q25.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

864 SN Ps

5 Cross References

17 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results