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Gene : GFRA1 Homo sapiens

Name  ? GDNF family receptor alpha 1 Cytological Location  10q25.3
Brief Description  GDNF family receptor alpha 1
Description  This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
  • synonyms:
  • GDNFR,
  • HGNC:4243,
  • RETL1,
  • RET1L,
  • GFR-ALPHA-1,
  • GDNFR,
  • GFRA1,
  • TRNR1,
  • TRNR1,
  • RET1L,
  • AF038421,
  • OTTHUMG00000019097,
  • RETL1,
  • GFR-ALPHA-1,
  • NM_145793,
  • uc009xyr.4
  • identifiers:
  • 2674,
  • ENSG00000151892,
  • GFRA1

Genome feature

Region: gene ? Length: 216721  
Location: 10:116056925-116273645 reverse strand Cyto location: 10q25.3

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0 Diseases

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864 SN Ps

5 Cross References

17 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results