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Gene : GFRA2 Homo sapiens

Name  ? GDNF family receptor alpha 2 Cytological Location  8p21.3
Brief Description  GDNF family receptor alpha 2
Description  Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
  • synonyms:
  • TRNR2,
  • GDNFRB,
  • NM_001495,
  • HGNC:4244,
  • NTNRA,
  • AF002700,
  • NTNRA,
  • RETL2,
  • GDNFRB,
  • GFRA2,
  • NRTNR-ALPHA,
  • OTTHUMG00000163897,
  • RETL2,
  • TRNR2,
  • uc064kuz.1
  • identifiers:
  • 2675,
  • ENSG00000168546,
  • GFRA2

Genome feature

Region: gene ? Length: 98899  
Location: 8:21690398-21789296 reverse strand Cyto location: 8p21.3


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Disease

0 Diseases

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3753 SN Ps

5 Cross References

16 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results