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Gene : CYTH4 Homo sapiens

Name  ? cytohesin 4 Cytological Location  22q13.1
Brief Description  cytohesin 4
Description  This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
  • synonyms:
  • cytohesin-4,
  • CYT4,
  • pleckstrin homology, Sec7 and coiled-coil domains 4,
  • DJ63G5.1,
  • OTTHUMG00000150562,
  • CYT4,
  • cytohesin-4,
  • PSCD4,
  • CYTH4,
  • AF075458,
  • NM_001318024,
  • PSCD4,
  • pleckstrin homology, Sec7 and coiled/coil domains 4,
  • HGNC:9505,
  • uc003arf.4
  • identifiers:
  • 27128,
  • ENSG00000100055,
  • CYTH4

Genome feature

Region: gene ? Length: 32834  
Location: 22:37282508-37315341 Cyto location: 22q13.1

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0 Diseases

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439 SN Ps

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results