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Gene : GCLC Homo sapiens

Name  ? glutamate-cysteine ligase catalytic subunit Cytological Location  6p12.1
Brief Description  glutamate-cysteine ligase catalytic subunit
Description  Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
  • synonyms:
  • GCLC,
  • M90656,
  • GCS,
  • glutamate-cysteine ligase, catalytic subunit,
  • GCL,
  • HGNC:4311,
  • NM_001197115,
  • GLCL,
  • GCS,
  • uc003pbw.3,
  • GLCLC,
  • GLCL,
  • OTTHUMG00000160220,
  • GLCLC
  • identifiers:
  • 2729,
  • ENSG00000001084,
  • GCLC

Genome feature

Region: gene ? Length: 47761  
Location: 6:53497341-53545101 reverse strand Cyto location: 6p12.1


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Proteins

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SNPs

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Disease

2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

702 SN Ps

5 Cross References

20 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results