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Gene : GLE1 Homo sapiens

Name  ? GLE1 RNA export mediator Cytological Location  9q34.11
Brief Description  GLE1 RNA export mediator
Description  This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • GLE1 RNA export mediator (yeast),
  • hGLE1,
  • GLE1 RNA export mediator homolog (yeast),
  • HGNC:4315,
  • LCCS1,
  • CAAHC,
  • GLE1L,
  • NM_001003722,
  • GLE1L,
  • AF058922,
  • LCCS1,
  • uc004bvj.4,
  • GLE1, RNA export mediator,
  • GLE1 (yeast homolog)-like, RNA export mediator,
  • GLE1,
  • GLE1 RNA export mediator-like (yeast),
  • CAAHD,
  • hGLE1,
  • LCCS,
  • lethal congenital contracture syndrome 1,
  • OTTHUMG00000020749
  • identifiers:
  • 2733,
  • ENSG00000119392,
  • GLE1

Genome feature

Region: gene ? Length: 37601  
Location: 9:128504692-128542292 Cyto location: 9q34.11

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2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

18 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results