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Gene : GLI2 Homo sapiens

Name  ? GLI family zinc finger 2 Cytological Location  2q14.2
Brief Description  GLI family zinc finger 2
Description  This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]
  • synonyms:
  • THP2,
  • NM_005270,
  • tax helper protein 2,
  • uc010flp.4,
  • glioma-associated oncogene family zinc finger 2,
  • tax helper protein 1,
  • CJS,
  • THP2,
  • THP1,
  • THP1,
  • GLI-Kruppel family member GLI2,
  • HGNC:4318,
  • GLI2,
  • PHS2,
  • HPE9,
  • OTTHUMG00000153741,
  • tax-responsive element-2 holding protein,
  • HPE9
  • identifiers:
  • 2736,
  • ENSG00000074047,
  • GLI2

Genome feature

Region: gene ? Length: 256786  
Location: 2:120735868-120992653 Cyto location: 2q14.2


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Proteins

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SNPs

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Disease

2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Expression

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Other

526 SN Ps

5 Cross References

20 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results