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Gene : GLUL Homo sapiens

Name  ? glutamate-ammonia ligase Cytological Location  1q25.3
Brief Description  glutamate-ammonia ligase
Description  The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
  • synonyms:
  • OTTHUMG00000037407,
  • GS,
  • GLNS,
  • GLUL,
  • glutamate-ammonia ligase (glutamine synthase),
  • GLNS,
  • HGNC:4341,
  • NM_002065,
  • PIG59,
  • AL161952,
  • PIG43,
  • glutamine synthetase,
  • uc001gpd.2
  • identifiers:
  • 2752,
  • ENSG00000135821,
  • GLUL

Genome feature

Region: gene ? Length: 14114  
Location: 1:182378093-182392206 reverse strand Cyto location: 1q25.3


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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Other

783 SN Ps

5 Cross References

19 Data Sets

12 Homologues

0 Located Features

97 Rna Seq Results