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Gene : GNRHR Homo sapiens

Name  ? gonadotropin releasing hormone receptor Cytological Location  4q13.2
Brief Description  gonadotropin releasing hormone receptor
Description  This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • GNRHR,
  • uc003hdn.4,
  • GNRHR1,
  • OTTHUMG00000129302,
  • LHRHR,
  • gonadotropin-releasing hormone receptor,
  • NM_000406,
  • LRHR,
  • HH7,
  • HGNC:4421,
  • GRHR,
  • GRHR,
  • LHRHR
  • identifiers:
  • 2798,
  • ENSG00000109163,
  • GNRHR

Genome feature

Region: gene ? Length: 17271  
Location: 4:67737118-67754388 reverse strand Cyto location: 4q13.2


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1 Diseases

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3753 SN Ps

5 Cross References

19 Data Sets

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0 Located Features

97 Rna Seq Results