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Gene : CES4A Homo sapiens

Name  ? carboxylesterase 4A Cytological Location  16q22.1
Brief Description  carboxylesterase 4A
Description  This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]
  • synonyms:
  • CES4A,
  • HGNC:26741,
  • uc010vix.3,
  • CES8,
  • FLJ37464,
  • AK094783,
  • CES6,
  • NM_173815,
  • OTTHUMG00000167866,
  • CES8,
  • carboxylesterase 8 (putative)
  • identifiers:
  • 283848,
  • ENSG00000172824,
  • CES4A

Genome feature

Region: gene ? Length: 21829  
Location: 16:66988589-67010417 Cyto location: 16q22.1

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Proteins.


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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

150 SNPs

4 Cross References

13 Data Sets

29 Homologues

0 Located Features

97 Rna Seq Results