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Gene : ANGPT1 Homo sapiens

Name  ? angiopoietin 1 Cytological Location  8q23.1
Brief Description  angiopoietin 1
Description  This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Mutations in this gene are associated with hereditary angioedema. [provided by RefSeq, Aug 2020]
  • synonyms:
  • Ang1,
  • KIAA0003,
  • ANGPT1,
  • NM_139290,
  • NM_001146,
  • ANG1,
  • AGP1,
  • AGPT,
  • HGNC:484,
  • D13628,
  • uc003ymn.4,
  • OTTHUMG00000164812
  • identifiers:
  • 284,
  • ENSG00000154188,
  • ANGPT1

Genome feature

Region: gene ? Length: 248437  
Location: 8:107249482-107497918 reverse strand Cyto location: 8q23.1

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Gene -> HPO annotation (Human Phenotype Ontology)

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



363 SN Ps

5 Cross References

17 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results