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Gene : GRB2 Homo sapiens

Name  ? growth factor receptor bound protein 2 Cytological Location  17q25.1
Brief Description  growth factor receptor bound protein 2
Description  The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • uc002jnx.5,
  • ASH,
  • OTTHUMG00000134332,
  • NCKAP2,
  • MST084,
  • NCKAP2,
  • HGNC:4566,
  • growth factor receptor-bound protein 2,
  • MSTP084,
  • NM_002086,
  • GRB2,
  • Grb3-3
  • identifiers:
  • 2885,
  • ENSG00000177885,
  • GRB2

Genome feature

Region: gene ? Length: 87634  
Location: 17:75318076-75405709 reverse strand Cyto location: 17q25.1

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

18 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results