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Gene : GRB10 Homo sapiens

Name  ? growth factor receptor bound protein 10 Cytological Location  7p12.1
Brief Description  growth factor receptor bound protein 10
Description  The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
  • synonyms:
  • IRBP,
  • MEG1,
  • GRB10,
  • growth factor receptor-bound protein 10,
  • RSS,
  • OTTHUMG00000150622,
  • uc003tpl.3,
  • NM_005311,
  • GRB-IR,
  • Grb-10,
  • HGNC:4564
  • identifiers:
  • 2887,
  • ENSG00000106070,
  • GRB10

Genome feature

Region: gene ? Length: 203386  
Location: 7:50590068-50793453 reverse strand Cyto location: 7p12.1

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

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823 SN Ps

5 Cross References

17 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results