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Gene : GRIA4 Homo sapiens

Name  ? glutamate ionotropic receptor AMPA type subunit 4 Cytological Location  11q22.3
Brief Description  glutamate ionotropic receptor AMPA type subunit 4
Description  Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HGNC:4574,
  • GLURD,
  • GluA4,
  • GLUR4C,
  • GRIA4,
  • glutamate receptor, ionotrophic, AMPA 4,
  • NM_000829,
  • uc001pix.2,
  • GluA4,
  • OTTHUMG00000166236,
  • GLURD,
  • U16129,
  • GLUR4,
  • GLUR4
  • identifiers:
  • 2893,
  • ENSG00000152578,
  • GRIA4

Genome feature

Region: gene ? Length: 372553  
Location: 11:105609540-105982092 Cyto location: 11q22.3

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1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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3753 SN Ps

5 Cross References

19 Data Sets

16 Homologues

0 Located Features

97 Rna Seq Results