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Gene : GRN Homo sapiens

Name  ? granulin precursor Cytological Location  17q21.31
Brief Description  granulin precursor
Description  Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
  • synonyms:
  • uc002igp.3,
  • PCDGF,
  • progranulin,
  • HGNC:4601,
  • OTTHUMG00000181816,
  • PGRN,
  • CLN11,
  • PGRN,
  • GRN,
  • GEP,
  • CLN11,
  • PEPI,
  • NM_002087,
  • PCDGF,
  • GP88,
  • M75161
  • identifiers:
  • 2896,
  • ENSG00000030582,
  • GRN

Genome feature

Region: gene ? Length: 7805  
Location: 17:44345302-44353106 Cyto location: 17q21.31


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2 Diseases

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995 SN Ps

5 Cross References

19 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results