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Gene : GRM1 Homo sapiens

Name  ? glutamate metabotropic receptor 1 Cytological Location  6q24.3
Brief Description  glutamate metabotropic receptor 1
Description  This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  • synonyms:
  • PPP1R85,
  • OTTHUMG00000015752,
  • uc032xoi.2,
  • glutamate receptor, metabotropic 1,
  • NM_000838,
  • GRM1,
  • GPRC1A,
  • mGlu1,
  • SCA44,
  • SCAR13,
  • HGNC:4593,
  • MGLUR1,
  • U31215,
  • MGLUR1,
  • GPRC1A,
  • MGLU1,
  • protein phosphatase 1, regulatory subunit 85,
  • PPP1R85
  • identifiers:
  • 2911,
  • ENSG00000152822,
  • GRM1

Genome feature

Region: gene ? Length: 409968  
Location: 6:146027634-146437601 Cyto location: 6q24.3

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



782 SN Ps

5 Cross References

20 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results