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Gene : CD274 Homo sapiens

Name  ? CD274 molecule Cytological Location  9p24.1
Brief Description  CD274 molecule
Description  This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
  • synonyms:
  • PD-L1,
  • PDCD1LG1,
  • PDL1,
  • B7H1,
  • HGNC:17635,
  • hPD-L1,
  • NM_014143,
  • B7-H,
  • PDCD1L1,
  • programmed cell death 1 ligand 1,
  • B7H1,
  • PDL1,
  • CD274 antigen,
  • B7 homolog 1,
  • CD274,
  • B7-H1,
  • AF177937,
  • B7-H,
  • OTTHUMG00000019503,
  • uc003zje.4,
  • PDCD1LG1,
  • PD-L1
  • identifiers:
  • 29126,
  • ENSG00000120217,
  • CD274

Genome feature

Region: gene ? Length: 20065  
Location: 9:5450503-5470567 Cyto location: 9p24.1

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

16 Data Sets

8 Homologues

0 Located Features

97 Rna Seq Results