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Gene : GSTA3 Homo sapiens

Name  ? glutathione S-transferase alpha 3 Cytological Location  6p12.2
Brief Description  glutathione S-transferase alpha 3
Description  Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
  • synonyms:
  • NM_000847,
  • AF020919,
  • uc003pbb.4,
  • GTA3,
  • GSTA3,
  • glutathione S-transferase A3,
  • HGNC:4628,
  • OTTHUMG00000014865,
  • GSTA3-3
  • identifiers:
  • 2940,
  • ENSG00000174156,
  • GSTA3

Genome feature

Region: gene ? Length: 13154  
Location: 6:52896646-52909799 reverse strand Cyto location: 6p12.2


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Disease

0 Diseases

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Other

487 SN Ps

5 Cross References

17 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results