help  | about  | cite  | software

Gene : BLNK Homo sapiens

Name  ? B cell linker Cytological Location  10q24.1
Brief Description  B cell linker
Description  This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
  • synonyms:
  • BASH,
  • BLNK-s,
  • SLP65,
  • bca,
  • Ly57,
  • SLP-65,
  • HGNC:14211,
  • B-cell adapter containing a SH2 domain protein,
  • LY57,
  • NM_013314,
  • Src homology [SH2] domain-containing leukocyte protein of 65 kD,
  • BLNK-S,
  • uc001kls.5,
  • AGM4,
  • SLP65,
  • BLNK,
  • B-cell activation,
  • OTTHUMG00000018827,
  • AF068180,
  • B cell adaptor containing SH2 domain,
  • bca,
  • SLP-65,
  • BASH
  • identifiers:
  • 29760,
  • ENSG00000095585,
  • BLNK

Genome feature

Region: gene ? Length: 82399  
Location: 10:96189171-96271569 reverse strand Cyto location: 10q24.1

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



138 SN Ps

5 Cross References

19 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results