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Gene : BLNK Homo sapiens

Name  ? B cell linker Cytological Location  10q24.1
Brief Description  B cell linker
Description  This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
  • synonyms:
  • SLP65,
  • LY57,
  • Ly57,
  • B-cell adapter containing a SH2 domain protein,
  • Src homology [SH2] domain-containing leukocyte protein of 65 kD,
  • BASH,
  • BASH,
  • BLNK-s,
  • uc001kls.5,
  • NM_013314,
  • bca,
  • BLNK,
  • bca,
  • SLP-65,
  • BLNK-S,
  • SLP-65,
  • HGNC:14211,
  • B cell adaptor containing SH2 domain,
  • AF068180,
  • AGM4,
  • B-cell activation,
  • SLP65,
  • OTTHUMG00000018827
  • identifiers:
  • 29760,
  • ENSG00000095585,
  • BLNK

Genome feature

Region: gene ? Length: 82406  
Location: 10:96189171-96271576 reverse strand Cyto location: 10q24.1


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Disease

1 Diseases

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Expression

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Other

138 SN Ps

5 Cross References

20 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results