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Function
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45 Pathways
- Class I MHC mediated antigen processing & presentation,
- Oocyte meiosis,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- Regulation of APC/C activators between G1/S and early anaphase,
- Antigen processing: Ubiquitination & Proteasome degradation,
- Autodegradation of Cdh1 by Cdh1:APC/C,
- Mitotic Anaphase,
- Ubiquitin mediated proteolysis,
- Generic Transcription Pathway,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- Cell Cycle Checkpoints,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- APC/C:Cdc20 mediated degradation of Securin,
- Synthesis of DNA,
- DNA Replication,
- Senescence-Associated Secretory Phenotype (SASP),
- Cell Cycle,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- APC/C-mediated degradation of cell cycle proteins,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- Cellular Senescence,
- Cellular responses to external stimuli,
- Progesterone-mediated oocyte maturation,
- Phosphorylation of the APC/C,
- CDK-mediated phosphorylation and removal of Cdc6,
- APC-Cdc20 mediated degradation of Nek2A,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- Adaptive Immune System,
- Switching of origins to a post-replicative state,
- Cell Cycle, Mitotic,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- M Phase,
- RNA Polymerase II Transcription,
- Mitotic Spindle Checkpoint,
- Separation of Sister Chromatids,
- Gene expression (Transcription),
- S Phase,
- Cellular responses to stress,
- Cell cycle,
- Transcriptional Regulation by VENTX,
- Mitotic Metaphase and Anaphase,
- Immune System,
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint,
- Regulation of mitotic cell cycle
Gene --> GO terms.
Gene -> HPO annotation (Human Phenotype Ontology)
Mouse Gene --> Allele [Phenotype]
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Gene --> Chromosomal location.
Gene --> GO terms.
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Disease
Gene (Hum OR Rat) --> Mouse Allele (Phenotype)
Gene --> Alleles and Disease (clinVar data)
Gene -> HPO annotation (Human Phenotype Ontology)
Mouse Gene --> Allele [Phenotype]
Other
45 Pathways
- Class I MHC mediated antigen processing & presentation,
- Oocyte meiosis,
- Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components,
- Regulation of APC/C activators between G1/S and early anaphase,
- Antigen processing: Ubiquitination & Proteasome degradation,
- Autodegradation of Cdh1 by Cdh1:APC/C,
- Mitotic Anaphase,
- Ubiquitin mediated proteolysis,
- Generic Transcription Pathway,
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A,
- Cell Cycle Checkpoints,
- Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins,
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase,
- APC/C:Cdc20 mediated degradation of Securin,
- Synthesis of DNA,
- DNA Replication,
- Senescence-Associated Secretory Phenotype (SASP),
- Cell Cycle,
- APC/C:Cdc20 mediated degradation of Cyclin B,
- APC/C-mediated degradation of cell cycle proteins,
- APC/C:Cdc20 mediated degradation of mitotic proteins,
- Cellular Senescence,
- Cellular responses to external stimuli,
- Progesterone-mediated oocyte maturation,
- Phosphorylation of the APC/C,
- CDK-mediated phosphorylation and removal of Cdc6,
- APC-Cdc20 mediated degradation of Nek2A,
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,
- Adaptive Immune System,
- Switching of origins to a post-replicative state,
- Cell Cycle, Mitotic,
- Inactivation of APC/C via direct inhibition of the APC/C complex,
- M Phase,
- RNA Polymerase II Transcription,
- Mitotic Spindle Checkpoint,
- Separation of Sister Chromatids,
- Gene expression (Transcription),
- S Phase,
- Cellular responses to stress,
- Cell cycle,
- Transcriptional Regulation by VENTX,
- Mitotic Metaphase and Anaphase,
- Immune System,
- APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint,
- Regulation of mitotic cell cycle