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Gene : DNMT3L Homo sapiens

Name  ? DNA methyltransferase 3 like Cytological Location  21q22.3
Brief Description  DNA methyltransferase 3 like
Description  CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
  • synonyms:
  • MGC1090,
  • OTTHUMG00000086914,
  • NM_013369,
  • DNMT3L,
  • HGNC:2980,
  • DNA (cytosine-5-)-methyltransferase 3-like,
  • AF194032,
  • cytosine-5-methyltransferase 3-like protein,
  • uc002zeh.2
  • identifiers:
  • 29947,
  • ENSG00000142182,
  • DNMT3L

Genome feature

Region: gene ? Length: 15559  
Location: 21:44246339-44261897 reverse strand Cyto location: 21q22.3

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0 Diseases

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2 SN Ps

5 Cross References

16 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results