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Gene : HGF Homo sapiens

Name  ? hepatocyte growth factor Cytological Location  7q21.11
Brief Description  hepatocyte growth factor
Description  This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
  • synonyms:
  • F-TCF,
  • HPTA,
  • F-TCF,
  • HPTA,
  • hepatopoietin A,
  • HGFB,
  • HGFB,
  • DFNB39,
  • NM_000601,
  • DFNB39,
  • uc003uhl.4,
  • fibroblast-derived tumor cytotoxic factor,
  • SF,
  • HGF,
  • SF,
  • deafness, autosomal recessive 39,
  • HGNC:4893,
  • lung fibroblast-derived mitogen,
  • OTTHUMG00000023804,
  • hepatocyte growth factor (hepapoietin A; scatter factor),
  • scatter factor
  • identifiers:
  • 3082,
  • ENSG00000019991,
  • HGF

Genome feature

Region: gene ? Length: 71433  
Location: 7:81699006-81770438 reverse strand Cyto location: 7q21.11


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Disease

1 Diseases

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Expression

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18 SN Ps

5 Cross References

20 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results