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Gene : CD209 Homo sapiens

Name  ? CD209 molecule Cytological Location  19p13.2
Brief Description  CD209 molecule
Description  This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020]
  • synonyms:
  • CD209,
  • uc002mht.3,
  • CLEC4L,
  • CLEC4L,
  • DC-SIGN1,
  • DC-SIGN,
  • DC-SIGN1,
  • DC-SIGN,
  • M98457,
  • HGNC:1641,
  • NM_021155,
  • OTTHUMG00000182530,
  • CD209 antigen
  • identifiers:
  • 30835,
  • ENSG00000090659,
  • CD209

Genome feature

Region: gene ? Length: 7542  
Location: 19:7739993-7747534 reverse strand Cyto location: 19p13.2

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



269 SN Ps

5 Cross References

17 Data Sets

22 Homologues

0 Located Features

97 Rna Seq Results