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Gene : HLA-DRB3 Homo sapiens

Name  ? major histocompatibility complex, class II, DR beta 3 Cytological Location  6p21.3
Description  HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]
  • synonyms:
  • HLA-DR3B,
  • NM_022555,
  • HLA-DR1B,
  • GL000251,
  • OTTHUMG00000012609,
  • DRB3,
  • GL000250,
  • HGNC:4951,
  • uc011ixb.4,
  • HLA-DPB1,
  • HLA-DR3B,
  • BC008987,
  • GL000255
  • identifiers:
  • 3125,
  • ENSG00000196101,
  • HLA-DRB3

Genome feature

Region: gene ?
Location: No location information in HumanMine Cyto location: 6p21.3

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0 SN Ps

5 Cross References

9 Data Sets

14 Homologues

0 Located Features

0 Rna Seq Results