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Gene : HNMT Homo sapiens

Name  ? histamine N-methyltransferase Cytological Location  2q22.1
Brief Description  histamine N-methyltransferase
Description  In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • uc002tvf.4,
  • HNMT,
  • HGNC:5028,
  • MRT51,
  • HNMT-S1,
  • NM_001024074,
  • HNMT-S2,
  • OTTHUMG00000131751,
  • HMT
  • identifiers:
  • 3176,
  • ENSG00000150540,
  • HNMT

Genome feature

Region: gene ? Length: 52297  
Location: 2:137964068-138016364 Cyto location: 2q22.1

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Report --> GWAS hit


2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



713 SN Ps

5 Cross References

18 Data Sets

0 Homologues

0 Located Features

97 Rna Seq Results