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Gene : HOXD8 Homo sapiens

Name  ? homeobox D8 Cytological Location  2q31.1
Brief Description  homeobox D8
Description  This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
  • synonyms:
  • HGNC:5139,
  • homeo box D8,
  • HOX4,
  • HOX4E,
  • HOXD8,
  • HOX5.4,
  • HOX4,
  • OTTHUMG00000132513,
  • uc002uko.4,
  • NM_001199746,
  • HOX4E
  • identifiers:
  • 3234,
  • ENSG00000175879,
  • HOXD8

Genome feature

Region: gene ? Length: 2991  
Location: 2:176129705-176132695 Cyto location: 2q31.1


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Function

Gene Ontology Displayer

0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 Pathways

333 SN Ps

5 Cross References

13 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results