HumanMine: Gene APC Homo sapiens

Quick Links:

Summary Function Genomics Proteins SNPs Disease Homology Interactions Expression Gene Ontology Other

Quick Links:

Summary Function Genomics Proteins SNPs Disease Homology Interactions Expression Gene Ontology Other

Lists

This Gene is in 2 lists:

PL_Protein coding cancer genes containing probable driver mutations (94)
PL_BHF_UCL_cardiovascGenes (4103)

Links to other Mines

FlyMine

No results

MouseMine

No results

YeastMine

No results

RatMine

No results

ZebrafishMine

No results

External Links

ensembl
BioGPS
ArrayExpress Atlas
Clinvar
NCBI entrez
HuGe
BioGRID

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

37 Pathways

Deubiquitination,
Deactivation of the beta-catenin transactivating complex,
Colorectal cancer,
S37 mutants of beta-catenin aren't phosphorylated,
S33 mutants of beta-catenin aren't phosphorylated,
Apoptosis,
AMER1 mutants destabilize the destruction complex,
AXIN mutants destabilize the destruction complex, activating WNT signaling,
Metabolism of proteins,
Degradation of beta-catenin by the destruction complex,
Post-translational protein modification,
Apoptotic execution phase,
Disassembly of the destruction complex and recruitment of AXIN to the membrane,
truncated APC mutants destabilize the destruction complex,
T41 mutants of beta-catenin aren't phosphorylated,
Wnt signaling pathway,
Misspliced GSK3beta mutants stabilize beta-catenin,
Apoptotic cleavage of cellular proteins,
Endometrial cancer,
Ovarian tumor domain proteases,
APC truncation mutants are not K63 polyubiquitinated,
APC truncation mutants have impaired AXIN binding,
AXIN missense mutants destabilize the destruction complex,
Regulation of actin cytoskeleton,
TCF dependent signaling in response to WNT,
Disease,
Truncations of AMER1 destabilize the destruction complex,
Beta-catenin phosphorylation cascade,
Basal cell carcinoma,
Programmed Cell Death,
Signaling by WNT in cancer,
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex,
Pathways in cancer,
Signaling by WNT,
Signal Transduction,
S45 mutants of beta-catenin aren't phosphorylated,
Diseases of signal transduction

Gene --> GO terms.

Search for GO annotations for a particular gene (or List of Genes).

Gene -> HPO annotation (Human Phenotype Ontology)

For a gene or list of genes show the Human Phenotype Ontology annotations.

Mouse Gene --> Allele [Phenotype]

For a given mouse Gene (or List of Genes) returns the alleles (MGI) and associated (major) Phenotypic terms (MGI). [keywords: allele, strain, phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Show the chromosome and the chromosome location of a particular gene.

Gene --> GO terms.

Search for GO annotations for a particular gene (or List of Genes).

Gene --> Overlapping genes.

For a particular gene, search for overlapping genes.

Proteins

Gene --> Proteins.

For a given Gene (or List of Genes) returns the corresponding Protein(s) products.

SNPs

Gene Report --> GWAS hit

Admin template to display GWAS results in Gene report pages. Do not use. Instead use: Gene --> GWAS hit

Disease

5 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

For a given Gene (or List of Genes) in named organism (default: Human) returns the orthologues in a different organisms (default : Mouse), alleles (MGI) and associated (major) Phenotypic terms (MGI). [keywords: homologue, homolog, paralogue, paralogue, ortholog, allele, strain, phenotype]

Gene --> Alleles and Disease (clinVar data)

For a gene, show alleles and any associated diseases. (Data from ClinVar: https://www.ncbi.nlm.nih.gov/clinvar/)

Gene -> HPO annotation (Human Phenotype Ontology)

For a gene or list of genes show the Human Phenotype Ontology annotations.

Mouse Gene --> Allele [Phenotype]

For a given mouse Gene (or List of Genes) returns the alleles (MGI) and associated (major) Phenotypic terms (MGI). [keywords: allele, strain, phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

For a given Gene (or List of Genes) in named organism (default: Human) returns the orthologues in a different organisms. [keywords: homologue, homolog, paralogue, paralogue, ortholog]

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

For a specified gene, show physical and genetic interaction partners. Optionally constrain to show just physical or genetic interactions or interactions determined by a specific method.

Expression

Gene(s) --> Significant SNPs (GTex data)

For a gene or list of genes show significant single-tissue cis-E-QTL SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

Search for GO annotations for a particular gene (or List of Genes).

Other

37 Pathways

Deubiquitination,
Deactivation of the beta-catenin transactivating complex,
Colorectal cancer,
S37 mutants of beta-catenin aren't phosphorylated,
S33 mutants of beta-catenin aren't phosphorylated,
Apoptosis,
AMER1 mutants destabilize the destruction complex,
AXIN mutants destabilize the destruction complex, activating WNT signaling,
Metabolism of proteins,
Degradation of beta-catenin by the destruction complex,
Post-translational protein modification,
Apoptotic execution phase,
Disassembly of the destruction complex and recruitment of AXIN to the membrane,
truncated APC mutants destabilize the destruction complex,
T41 mutants of beta-catenin aren't phosphorylated,
Wnt signaling pathway,
Misspliced GSK3beta mutants stabilize beta-catenin,
Apoptotic cleavage of cellular proteins,
Endometrial cancer,
Ovarian tumor domain proteases,
APC truncation mutants are not K63 polyubiquitinated,
APC truncation mutants have impaired AXIN binding,
AXIN missense mutants destabilize the destruction complex,
Regulation of actin cytoskeleton,
TCF dependent signaling in response to WNT,
Disease,
Truncations of AMER1 destabilize the destruction complex,
Beta-catenin phosphorylation cascade,
Basal cell carcinoma,
Programmed Cell Death,
Signaling by WNT in cancer,
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex,
Pathways in cancer,
Signaling by WNT,
Signal Transduction,
S45 mutants of beta-catenin aren't phosphorylated,
Diseases of signal transduction

Name	APC regulator of WNT signaling pathway	Cytological Location	5q22.2
Brief Description	APC regulator of WNT signaling pathway

Region:	gene	Length:	138742
Location:	5:112707498-112846239	Cyto location:	5q22.2

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /humanmine/portal.do?id=1105930

HumanMine

Gene : APC Homo sapiens

Genome feature

Links to other Mines

External Links

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

37 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

5 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

Other

37 Pathways

711 SN Ps

5 Cross References

20 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results