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Gene : APC Homo sapiens

Name  ? APC regulator of WNT signaling pathway Cytological Location  5q22.2
Brief Description  APC regulator of WNT signaling pathway
Description  This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019]
  • synonyms:
  • BTPS2,
  • DP2.5,
  • APC,
  • PPP1R46,
  • M74088,
  • OTTHUMG00000128806,
  • DESMD,
  • GS,
  • HGNC:583,
  • DP2,
  • uc003kpy.5,
  • APC, WNT signaling pathway regulator,
  • DP3,
  • DP3,
  • adenomatous polyposis coli,
  • adenomatosis polyposis coli,
  • NM_000038,
  • PPP1R46,
  • protein phosphatase 1, regulatory subunit 46,
  • DP2.5,
  • DP2
  • identifiers:
  • 324,
  • ENSG00000134982,
  • APC

Genome feature

Region: gene ? Length: 138742  
Location: 5:112707498-112846239 Cyto location: 5q22.2

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Gene -> HPO annotation (Human Phenotype Ontology)

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5 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



711 SN Ps

5 Cross References

19 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results