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Gene : APLP2 Homo sapiens

Name  ? amyloid beta precursor like protein 2 Cytological Location  11q24.3
Brief Description  amyloid beta precursor like protein 2
Description  This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  • synonyms:
  • uc010sby.3,
  • OTTHUMG00000165767,
  • HGNC:598,
  • NM_001642,
  • APPH,
  • APLP-2,
  • APLP2,
  • APPH,
  • CDEBP,
  • amyloid beta (A4) precursor-like protein 2,
  • APPL2,
  • APPL2,
  • L19597
  • identifiers:
  • 334,
  • ENSG00000084234,
  • APLP2

Genome feature

Region: gene ? Length: 74912  
Location: 11:130069894-130144805 Cyto location: 11q24.3

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



379 SN Ps

5 Cross References

17 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results