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Gene : HTR2C Homo sapiens

Name  ? 5-hydroxytryptamine receptor 2C Cytological Location  Xq23
Brief Description  5-hydroxytryptamine receptor 2C
Description  This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
  • synonyms:
  • HTR1C,
  • 5-HT2C,
  • 5-HT2C,
  • 5-HT1C,
  • 5-HTR2C,
  • uc004epu.1,
  • 5-hydroxytryptamine (serotonin) receptor 2C,
  • 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled,
  • HTR1C,
  • HTR2C,
  • NM_000868,
  • OTTHUMG00000022226,
  • 5HTR2C,
  • HGNC:5295,
  • 5HTR2C
  • identifiers:
  • 3358,
  • ENSG00000147246,
  • HTR2C

Genome feature

Region: gene ? Length: 325976  
Location: X:114584086-114910061 Cyto location: Xq23

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0 Diseases

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598 SNPs

5 Cross References

15 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results