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Gene : GPR149 Homo sapiens

Name  ? G protein-coupled receptor 149 Cytological Location  3q25.2
Brief Description  G protein-coupled receptor 149
Description  This gene encodes a seven-transmembrane G protein coupled receptor (GPCR) class A family member. Although categorized as a class A GPCR, the encoded protein lacks the first two charged amino acids of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix of class A receptors which is important for efficient G protein-coupled signal transduction. Mice with a knockout of the orthologous gene are viable and have normal maturation of the ovarian follicle, but show enhanced fertility and ovulation. All GPCRs have a common structural architecture consisting of seven transmembrane alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptor, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
  • synonyms:
  • OTTHUMG00000159131,
  • IEDA,
  • PGR10,
  • NM_001038705,
  • R35,
  • HGNC:23627,
  • PGR10,
  • R35,
  • AY255534,
  • uc003faa.3,
  • IEDA,
  • GPR149
  • identifiers:
  • 344758,
  • ENSG00000174948,
  • GPR149

Genome feature

Region: gene ? Length: 95248  
Location: 3:154334943-154430190 reverse strand Cyto location: 3q25.2

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

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Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

46 SN Ps

4 Cross References

14 Data Sets

2 Homologues

0 Located Features

97 Rna Seq Results