help  | about  | cite  | software

Gene : IGFBP1 Homo sapiens

Name  ? insulin like growth factor binding protein 1 Cytological Location  7p12.3
Brief Description  insulin like growth factor binding protein 1
Description  This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]
  • synonyms:
  • IBP1,
  • AFBP,
  • binding protein-25,
  • uc003tnp.4,
  • IGF-BP25,
  • HGNC:5469,
  • hIGFBP-1,
  • alpha-pregnancy-associated endometrial globulin,
  • insulin-like growth factor binding protein 1,
  • binding protein-28,
  • placental protein 12,
  • PP12,
  • amniotic fluid binding protein,
  • IGFBP1,
  • IGF-BP25,
  • hIGFBP-1,
  • IGF-binding protein 1,
  • NM_000596,
  • PP12,
  • AFBP,
  • growth hormone independent-binding protein,
  • OTTHUMG00000152343,
  • IBP1,
  • binding protein-26
  • identifiers:
  • 3484,
  • ENSG00000146678,
  • IGFBP1

Genome feature

Region: gene ? Length: 5173  
Location: 7:45888488-45893660 Cyto location: 7p12.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

20 SN Ps

5 Cross References

15 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results