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Gene : APOH Homo sapiens

Name  ? apolipoprotein H Cytological Location  17q24.2
Brief Description  apolipoprotein H
Description  Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019]
  • synonyms:
  • apolipoprotein H (beta-2-glycoprotein I),
  • beta-2-glycoprotein I,
  • uc002jfn.5,
  • B2G1,
  • HGNC:616,
  • APOH,
  • BG,
  • BG,
  • B2GP1,
  • OTTHUMG00000179530,
  • NM_000042,
  • B2G1
  • identifiers:
  • 350,
  • ENSG00000091583,
  • APOH

Genome feature

Region: gene ? Length: 17383  
Location: 17:66212033-66229415 reverse strand Cyto location: 17q24.2


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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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Expression

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Other

25 SN Ps

5 Cross References

16 Data Sets

6 Homologues

2 Located Features

97 Rna Seq Results