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Gene : APP Homo sapiens

Name  ? amyloid beta precursor protein Cytological Location  21q21.3
Brief Description  amyloid beta precursor protein
Description  This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
  • synonyms:
  • AD1,
  • AAA,
  • CVAP,
  • AD1,
  • preA4,
  • NM_000484,
  • PN2,
  • peptidase nexin-II,
  • Alzheimer disease,
  • M15533,
  • HGNC:620,
  • ABPP,
  • APP,
  • OTTHUMG00000078438,
  • amyloid beta (A4) precursor protein,
  • ABETA,
  • PN-II,
  • APPI,
  • uc002ylz.4,
  • CTFgamma
  • identifiers:
  • 351,
  • ENSG00000142192,
  • APP

Genome feature

Region: gene ? Length: 290579  
Location: 21:25880550-26171128 reverse strand Cyto location: 21q21.3

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64 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



64 Pathways

678 SN Ps

5 Cross References

20 Data Sets

6 Homologues

3 Located Features

97 Rna Seq Results