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Gene : IGLL1 Homo sapiens

Name  ? immunoglobulin lambda like polypeptide 1 Cytological Location  22q11.23
Brief Description  immunoglobulin lambda like polypeptide 1
Description  The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • IGL1,
  • IGO,
  • X52204,
  • OTTHUMG00000150673,
  • IGL5,
  • HGNC:5870,
  • VPREB2,
  • NM_020070,
  • IGVPB,
  • IGLJ14.1,
  • IGVPB,
  • AGM2,
  • lambda 5,
  • uc002zxd.4,
  • IGLL1,
  • 14.1,
  • 14.1,
  • CD179b,
  • IGL5,
  • CD179B,
  • IGLL,
  • IGLL,
  • immunoglobulin lambda-like polypeptide 1
  • identifiers:
  • 3543,
  • ENSG00000128322,
  • IGLL1

Genome feature

Region: gene ? Length: 7166  
Location: 22:23573125-23580290 reverse strand Cyto location: 22q11.23


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Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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85 SN Ps

5 Cross References

20 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results