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Gene : FAS Homo sapiens

Name  ? Fas cell surface death receptor Cytological Location  10q23.31
Brief Description  Fas cell surface death receptor
Description  The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
  • synonyms:
  • APT1,
  • M67454,
  • FASTM,
  • CD95,
  • TNFRSF6,
  • TNF receptor superfamily member 6,
  • CD95,
  • tumor necrosis factor receptor superfamily, member 6,
  • Fas (TNF receptor superfamily, member 6),
  • ALPS1A,
  • FAS1,
  • uc001kfr.4,
  • OTTHUMG00000018701,
  • APO-1,
  • APO-1,
  • HGNC:11920,
  • APT1,
  • FAS1,
  • TNFRSF6,
  • NM_000043,
  • FAS
  • identifiers:
  • 355,
  • ENSG00000026103,
  • FAS

Genome feature

Region: gene ? Length: 48631  
Location: 10:88968429-89017059 Cyto location: 10q23.31


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Disease

1 Diseases

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3753 SN Ps

5 Cross References

20 Data Sets

4 Homologues

2 Located Features

97 Rna Seq Results