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Gene : FASLG Homo sapiens

Name  ? Fas ligand Cytological Location  1q24.3
Brief Description  Fas ligand
Description  This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]
  • synonyms:
  • OTTHUMG00000034841,
  • CD178,
  • CD95-L,
  • TNLG1A,
  • U11821,
  • FasL,
  • ALPS1B,
  • uc001gis.4,
  • FASLG,
  • FASL,
  • Fas ligand (TNF superfamily, member 6),
  • APT1LG1,
  • TNFSF6,
  • CD178,
  • TNFSF6,
  • APT1LG1,
  • HGNC:11936,
  • CD95L,
  • NM_000639,
  • APTL,
  • tumor necrosis factor (ligand) superfamily, member 6
  • identifiers:
  • 356,
  • ENSG00000117560,
  • FASLG

Genome feature

Region: gene ? Length: 7869  
Location: 1:172659008-172666876 Cyto location: 1q24.3


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Gene -> HPO annotation (Human Phenotype Ontology)

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Proteins

Gene --> Proteins.

SNPs

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Disease

2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

31 SN Ps

5 Cross References

19 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results